Stevens Receives New Patent for Mass Spectrometry Technique

Mass spectrometry (MS) is a powerful analytical tool used to measure the masses of molecules.  It is also one of the most sensitive methods available for detection and characterization of chemical compounds. In order to carry out mass spectrometric analysis, the molecules must be vaporized and electrically charged.

Stevens researchers have received a patent for a new mass spectrometric technique called Helium-Plasma Ionization Mass Spectrometry (HePI-MS). This versatile ionization method enables sampling of materials under ambient conditions by placing them directly in the spectrometer.

Stevens has signed a licensing agreement with Plasmionix, LLC, who will develop, together with Scientific Analytical Instruments (SAI) in Manchester, United Kingdom, this technology invented by Athula Buddhagosha Attygalle, a Research Professor in the Department of Chemistry, Chemical Biology & Biomedical Engineering, and his colleagues.

In fact, Freneil Jariwala, a Stevens PhD graduate, has been recruited by SAI to implement the technology transfer. Postdoc Zhihua Yang and PhD candidates, Julius Pavlov and Rekha Gangam, also contributed to the development of the HePI-MS technique.

“We can tell if someone has washed their hands,” says Attygalle. “All of us carry a reasonable amount of lactic acid on our skin, and we get a signal for it just by placing your hands in the instrument.”

The Stevens technique also provides a rapid way to detect explosives, including inorganic substances, in amounts as tiny as one nanogram (one millionth of a milligram), for potential use at airports.

Attygale explains that many explosives use inorganic compounds, such as saltpeters. We are all aware, he says, of the disturbing reality of misuse of nitrate fertilizer for the construction of improvised explosive devices—all major ground terrorist attacks in the West—from the Oklahoma City bombing in 1995 to the events in Oslo in 2011, employed ammonium nitrate-based bombs.

“Most explosives are organic—carbon based,” says Attygalle. “Inorganic explosives are much harder to detect because they are mostly salts—they are less volatile.”

According to Attygalle, typical mass spectrometric techniques involve rigorous sample preparation, and extraction.  Overall analysis time and expense per sample can be significant. HePI-MS does not require most of these sample preparation procedures.

HePI-MS can be used for a variety of applications, from distinguishing brands of chewing gum to potential healthcare applications. Researchers actually inserted a cured sausage to show the presence of nitrates and showed nicotine in an unlit cigarette, the results of which were published in Analytical Chemistry, 2014 86 (1), 928-935.

“Eventually, we will be able to sample, for example, the breath of an unconscious patient who has overdosed on drugs to determine what they have taken,” says Attygalle. “This method has the potential to save lives.”

About Stevens Institute of Technology

Stevens Institute of TechnologyThe Innovation University®, is a premier, private research university situated in Hoboken, N.J. overlooking the Manhattan skyline. Founded in 1870, technological innovation has been the hallmark and legacy of Stevens’ education and research programs for more than 140 years. Within the university’s three schools and one college, more than 6,100 undergraduate and graduate students collaborate with more than 350 faculty members in an interdisciplinary, student-centric, entrepreneurial environment to advance the frontiers of science and leverage technology to confront global challenges. Stevens is home to three national research centers of excellence, as well as joint research programs focused on critical industries such as healthcare, energy, finance, defense, STEM education and coastal sustainability. The university is consistently ranked among the nation’s elite for return on investment for students, career services programs and mid-career salaries of alumni. Stevens is in the midst of a 10-year strategic plan, The Future. Ours to Create., designed to further extend the Stevens legacy to create a forward-looking and far-reaching institution with global impact.



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Author:NJ Tech Council

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